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I have two theories for why UFAP is now these ubiquitous assistance. The 1st is our fault for imagining as well narrowly. The 2nd is definitely the fault of professional medical tradition, for selling the idea of invincibility.

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Individuals days are extensive absent. As an alternative to regurgitating Very first Aid, now It's important to interpret Every single issue’s nuances. Why is definitely the affected individual with arm weak point presenting with superior blood pressure level?

When PDUFA II decreased the requisite amount of Phase III clinical trials for approval from two to at least one, this codified a observe by now set up at FDA; casual rules allowed just one trial to become recognized sometimes.31 Even so, the elevation of solitary-demo permissibility to statue marked a decline in the amount of new medicines even now adhering to the two-trial conventional. Foremost approximately PDUFA II’s passage in 1995–1997, 81% of latest drugs had been supported by two pivotal trials.32 This proportion declined to 53% by 2015–2017, at the same time as the standard of pivotal trials has also declined, in term of an increased use of placebo controls (as opposed to active comparators) and one-arm styles.

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“It’s the wizard, not the wand.” One of my anesthesia attendings during residency liked to mention this.

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